Applications for Bioprinting2019-09-20T01:36:56-07:00

Applications of BioPrinting

3D bioprinting is a revolutionary 3D biomanufacturing technology driving the field of regenerative medicine and tissue engineering into the future. Bioprinting enables the precise patterning and assembling of cells and extracellular matrix (ECM) in three-dimensions into functional tissue constructs built from a patient’s own cells. This technology will be a game changer in medicine. Bioprinting application areas range from drug screening and toxicology research to tissue and organ transplantation. Brinter™ strives to build technologies that advance the growing industry of 3D bioprinting.

 

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BASIC RESEARCH IN TISSUE ENGINEERING

  • Integration of bioprinting with stem cell research enables fabrication of microenvironments with spatially controlled gradients of immobilized biomolecules to direct stem cell fate.
    • Universities, research institutions, and hospitals benefit as these controlled microenvironments accelerate the process of learning to control stem cell differentiation.
  • Developing novel biomaterials designed for use in bioprinting plays an essential role in the future of bioprinting. Feasible bioink materials that are easily dispensable, mechanically robust, and able to maintain cellular viability is key to creating in vivo bioprinting applications.

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TISSUE MODELS FOR DRUG AND TOXICOLOGY SCREENING

  • Three-dimensional in vitro tissue models offer an ideal solution to various problems related to drug discovery. These 3D models will reduce financial and human resource investments needed to bring a new drug to market.
  • Bioprinting is a feasible method to create small-scale, simplified tissues like liver, kidney, or lung tissue, which mimic native tissue for high-throughput assays.
  • Myriad non-pharmaceutical applications including chemicals, consumer products, cosmetics, and agribusiness. These are often required to provide data on the efficacy and safety of their products on consumers and the environment. Safer and more efficacious products can be developed using biomimetic tissues instead of poorly predictive animal models.

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TISSUE MODELS FOR DRUG AND TOXICOLOGY SCREENING

  • Three-dimensional in vitro tissue models offer an ideal solution to various problems related to drug discovery. These 3D models will reduce financial and human resource investments needed to bring a new drug to market.
  • Bioprinting is a feasible method to create small-scale, simplified tissues like liver, kidney, or lung tissue, which mimic native tissue for high-throughput assays.
  • Myriad non-pharmaceutical applications including chemicals, consumer products, cosmetics, and agribusiness. These are often required to provide data on the efficacy and safety of their products on consumers and the environment. Safer and more efficacious products can be developed using biomimetic tissues instead of poorly predictive animal models.

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TISSUE MODELS FOR CANCER RESEARCH

  • Two-dimensional tumor models lack cell-cell and cell-matrix interactions present in 3D. They do not precisely represent a physiologically relevant environment.
  • Bioprinting recapitulates the complicated cancer microenvironment by precisely situating multiple cell types and even microcapillaries. This approach will benefit the study of cancer pathogenesis and metastasis.

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DRUG PRINTING

  • Bioprinting generates new ways to produce prescription pills. The US Food and Drug Administration already approved Spritam, the first bioprinted prescription drug to control epileptic seizures. Doses of the drug print from a set of biochemical inks customized for each patient.
  • Instead of taking many pills a day, future patients will take just one 3D printed composite pill that could contain multiple drugs each with a unique release rate.

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DRUG PRINTING

  • Bioprinting generates new ways to produce prescription pills. The US Food and Drug Administration already approved Spritam, the first bioprinted prescription drug to control epileptic seizures. Doses of the drug print from a set of biochemical inks customized for each patient.
  • Instead of taking many pills a day, future patients will take just one 3D printed composite pill that could contain multiple drugs each with a unique release rate.

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BIOPRINTED TISSUES AND ORGANS

  • A wide variety of tissues, such as blood vessels and nonvascularized cartilage, have been successfully bioprinted.
  • Eventually, it may be possible to 3D bioprint entire functional organs for those in need of organ transplant.
  • Incorporation of nerves, blood vessels, and lymphatic vessels capable of integrating with host systems will enable the creation of transplantable organs, such as kidneys, lungs, hearts, and livers. Before transition to clinics, artificial organs will be assessed via animal transplantation.

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