Process Chain of Medical 3D Printing and Solutions2018-11-09T03:33:51+00:00

Process Chain of BioPrinting with Brinter™

1. IMAGE ACQUISITION

  • Obtain medical images from the organ or tissue needing bioprinting through non-invasive imaging.
    • e.g. magnetic resonance imaging (MRI), computed tomography (CT), X-ray or ultrasound
  • Ready-to-print sample models of organs and tissues are also available online from National Institutes of Health (NIH) repository: https://3dprint.nih.gov/

2. IMAGE PROCESSING

  • Process image raw data through image segmentation using image-processing software.
  • Segmentation results in a 3D CAD surface model in .STL format. This represents the outer shape of the construct approximated using triangle mesh.
  • The medical image-based surface model is then filled with repeating unit cells. These can be found, for example, from a database of porous architectures. This then generates the complete construct with internal infrastructure.
  • Brinter software generates a toolpath plan as a g-code file from the 3D model. This provides the motion path for the bioprinter to deposit bioink at proper time and location.

2. IMAGE PROCESSING

  • Process image raw data through image segmentation using image-processing software.
  • Segmentation results in a 3D CAD surface model in .STL format. This represents the outer shape of the construct approximated using triangle mesh.
  • The medical image-based surface model is then filled with repeating unit cells. These can be found, for example, from a database of porous architectures. This then generates the complete construct with internal infrastructure.
  • Brinter software generates a toolpath plan as a g-code file from the 3D model. This provides the motion path for the bioprinter to deposit bioink at proper time and location.

3. 3D BIOPRINTING

  • A cell-laden hydrogel solution is prepared by mixing the cell suspension with the chosen hydrogel solution.
  • Prepared bioink is loaded into the Brinter bioprinter.
  • The predetermined bioprinting parameters are inserted into Duet3D software controlling the printing process.
  • The 3D bioprinter lays down successive layers of bioink and builds up the tissue model from a series of cross-sections.
  • Afterwards, the cell-laden construct can be chemically or physically cross-linked for structural integrity.

 

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